MOOC RPINDES
Rpindes, considera necesario e indispensable preparar jóvenes que puedan adquirir experiencias y poder desarrollar sus ideas.
Para ello es necesario tener un espacio donde publicar sus primeros trabajos, aprender a investigar, tener un tutor, revisar contenidos, aprender a resumir, buscar información en biblioteca y realizar un resumen en inglés.
Por nuestra experiencia cuando iniciamos en año 2000, hemos trabajado con alumnos de educación obligatoria, nuestro incentivo ha sido actualizar todos los contenidos científicos que recibimos de las revistas científicas donde estamos registrados. También hemos observados que los alumnos que inician las carreras de ciencias e ingenierías tienen las mismas dificultades en publicar sus primeros artículos y su posterior divulgación.
Sabemos que para obtener grandes éxitos en sus rendimientos académicos queremos aportar esta herramienta necesaria para desarrollar ideas a futuros científicos de este siglo XXI.
Publicaciones y citación
Diastereoselective synthesis of cularine alkaloids via enium ions and an easy entry to isoquinoli...
Citación:
β-Phenylethylamines and the isoquinoline alkaloids
KW Bentley - Natural product reports, 2006 - pubs.rsc.org
This review covers β-phenylethylamines and isoquinoline alkaloids derived from them,including further products of oxidation, condensation with formaldehyde and rearrangement,some of which do not
contain an isoquinoline system, together with naphthylisoquinoline.
Rapid synthesis of aryl azides from aryl halides under mild conditions
J Andersen, U Madsen, F Björkling, X Liang - Synlett, 2005 - thieme-connect.com
Abstract A rapid synthesis of aryl azides from the corresponding aryl halides catalyzed by CuI/diamine is described. Sodium ascorbate was found to have a positive effect
on stabilization of the catalyst system. The reactions were performed under very mild ...
Computational studies of the properties of phenyloxenium ions A comparison with phenylnitrenium and phenylcarbenium ions
SA Glover, M Novak - Canadian journal of chemistry, 2005 - NRC Research Press
Properties of phenyloxenium ion 13a, phenylnitrenium ion 14a, and their 4-methyl and 4-phenyl analogues have been studied at the HF/6-31G* and pBP/DN*//HF/6-31G* levels
to explain differences in their relative ease of formation and their stabilities. The ...
Supported Bilayer Lipid Membrane Arrays on Photopatterned Self‐Assembled Monolayers
X Han, SND Pradeep, K Critchley… - … -a European Journal, 2007 - Wiley Online Library
Abstract This work demonstrates the use of photocleavable cholesterol derivatives to create supported bilayer lipid membrane arrays on silica. The photocleavable cholesteryl
tether is attached to the surface by using the reaction of an amine-functionalized self-assembled ...
4'-Substituted-4-biphenylyloxenium ions: Reactivity and selectivity in aqueous solution
M Novak, MJ Poturalski, WL Johnson… - The Journal of …, 2006 - ACS Publications
Azide trapping shows that the 4'-substituted-4-biphenylyloxenium ions 1b-d are generated during hydrolysis of 4-aryl-4-acetoxy-2, 5-cyclohexadienones, 2c and 2d, and
O-(4-aryl) phenyl-N-methanesulfonylhydroxylamines, 3b and 3c. In addition, the 4'-bromo- ...
Direct detection of a transient oxenium ion in water generated by laser flash photolysis
YT Wang, J Wang, MS Platz… - Journal of the American …, 2007 - ACS Publications
Laser flash photolysis of the quinol ester 2b in O2-saturated aqueous phosphate buffer at pH 7.1 with excitation at 266 nm generates a transient intermediate with λmax 460 nm
that decays in a first-order manner with an aqueous solution lifetime of (170±10) ns at 22° C. ...
Chemoselective Aromatic Azido Reduction with Concomitant Aliphatic Azide Employing Al/Gd Triflates/NaI and ESI‐MS Mechanistic Studies
A Kamal, N Markandeya, N Shankaraiah… - … -A European Journal, 2009 - Wiley Online Library
Abstract Aluminium and gadolinium triflates catalyze the chemoselective reduction of aromatic azides to the corresponding amines in combination with sodium iodide. This
mild chemoselective method has been applied to the synthesis of various aryl amines, C2- ...
The first total synthesis of (±)-annosqualine by means of oxidative enamide–phenol coupling: pronounced effect of phenoxide formation on the phenol
oxidation …
H Shigehisa, J Takayama, T Honda - Tetrahedron letters, 2006 - Elsevier
The first total synthesis of a spiro-isoquinoline alkaloid,(±)-annosqualine, was established by employing an enamide–phenol coupling of a 1-methylene-1, 2, 3,
4-tetrahydroisoquinoline
derivative with a hypervalent iodine reagent, where the formation of the phenoxide was ...
derivative with a hypervalent iodine reagent, where the formation of the phenoxide was ...
The hydrolysis of 4-acyloxy-4-substituted-2, 5-cyclohexadienones: Limitations of aryloxenium ion chemistry
M Novak, SA Glover - Journal of the American Chemical Society, 2005 - ACS Publications
The title compounds serve as potential precursors to aryloxenium ions, often proposed, but primarily uncharacterized intermediates in phenol oxidations. The uncatalyzed and
acid-catalyzed decomposition of 4-acetoxy-4-phenyl-2, 5-cyclohexadienone, 2a, generates the ...
Characterization of reactive intermediates generated during photolysis of 4-acetoxy-4-aryl-2, 5-cyclohexadienones: Oxenium ions and aryloxy
radicals
YT Wang, KJ Jin, SH Leopold, J Wang… - Journal of the …, 2008 - ACS Publications
Aryloxenium ions 1 are reactive intermediates that are isoelectronic with the better known arylcarbenium and arylnitrenium ions. They are proposed to be involved in synthetically
and industrially useful oxidation reactions of phenols. However, mechanistic studies of these ...
Diaryl ether formation in the synthesis of natural products
EN Pitsinos, VP Vidali… - European Journal of …, 2011 - Wiley Online Library
Abstract The structural variety of naturally occurring diaryl ethers is illustrated and the various synthetic methods employed for the construction of diaryl ether
linkages in related total syntheses are reviewed. Examples of successful applications of each method ( ...
Ring closure reactions in heterocyclic systems with implementation of Wittig and aza-Wittig reactions
G Hajos, I Nagy - Current Organic Chemistry, 2008 - ingentaconnect.com
Abstract: Applications of Wittig and aza-Wittig reactions in various cyclizations reported during the past ten years are reviewed. The relevant literature is
classified into two categories according to these two main approaches and, in both sections, the chemistry is ...
Nitrenium ions: structure and reactivity
GI Borodkin, VG Shubin - Russian Chemical Reviews, 2008 - iopscience.iop.org
Abstract. Data on the structure and reactivity of different nitrenium ions are generalised and described systematically. Various reaction pathways of these reactive
intermediates resulted from their electronic structure are analysed. The attention is focused on the results of ...
An overview on benzylisoquinoline derivatives with dopaminergic and serotonergic activities
N Cabedo, I Berenguer, B Figadere… - Current medicinal …, 2009 - ingentaconnect.com
Abstract: Dopamine and serotonin are important neurotransmitters in the mammalian central nervous system (CNS) involved in numerous physiological and behavioural
disorders such as schizophrenia, major depression, anxiety, Parkinson's and Huntington's diseases, and ...
Diphenylnitrenium ion: Cyclization, electron transfer, and polymerization reactions
AC Kung, SP McIlroy, DE Falvey - The Journal of organic …, 2005 - ACS Publications
Reactions of diphenylnitrenium ion were examined using laser flash photolysis (LFP), product analysis, and computational modeling using density functional theory
(DFT). In the absence of trapping agents, diphenylnitrenium ion cyclizes to form carbazole. On the ...
Rapid access to pyrimido [5, 4-c] isoquinolines via a sulfur monoxide extrusion reaction
R Fu, X Xu, Q Dang, F Chen, X Bai - Organic Letters, 2007 - ACS Publications
The scope of a sulfur monoxide extrusion reaction of pyrimido [4, 5-b][1, 4] benzothiazepines leading to pyrimido [5, 4-c] isoquinolines was investigated. Thus,
selective oxidation followed by nucleophilic displacement of the oxidized side chain sulfur group and ...
Chemistry of 4-Alkylaryloxenium Ion “Precursors”: Sound and Fury Signifying Something?
M Novak, AM Brinster, JN Dickhoff, JM Erb… - The Journal of …, 2007 - ACS Publications
Quinol esters 2b, 2c, and 3b and sulfonamide 4c were investigated as possible precursors to 4-alkylaryloxenium ions, reactive intermediates that have not been
previously detected.
These compounds exhibit a variety of interesting reactions, but with one possible ...
These compounds exhibit a variety of interesting reactions, but with one possible ...
One-Pot Synthesis and Fungicidal Activities of Derivatives of Imidazo [2, 1-b]-1, 3, 4-thiadiazol-5 (6 H)-one
Y Sun, BQ Fu, MW Ding - Phosphorus, Sulfur, and Silicon, 2006 - Taylor & Francis
The isothiocyanates 2, obtained from aza-Wittig reactions of vinyliminophosphoranes 1 with CS 2, reacted with hydrazine to give 3-amino-2-thioxo-4-imidazolidinones 4.
One-pot reactions of 4, aromatic isocyanates, Ph 3 P, C 2 Cl 6, and Et 3 N generated imidazo [2, 1- ...
Carbocations
RA McClelland - … · 2006: An annual survey covering the …, 2003 - Wiley Online Library
Developments in the study of carbocations in superacid media over the past 30 years have been reviewed. 1 The thermodynamics [G (g)] of the reaction R+(g)+ Rref OH
(g)→ ROH (g)+R+ ref (g) involving Rref= t-butyl and 21 R+ has been studied by high-level computation. 2 ...
Synthesis of Tetrahydronaphthalene Lignan Esters by Intramolecular Cyclization of Ethyl p-Azidophenyl-2-phenylalkanoates and Evaluation of the Growth Inhibition of …
O Pinto, J Sardinha, PD Vaz, F Piedade… - Journal of medicinal …, 2011 - ACS
Publications
Intramolecular cyclization via nitrenium ion of 2-phenylpentanoic/2-phenylbutanoic acid esters with a terminal p-azidophenyl group gives direct access to
tetrahydronaphthalene lignan esters. The p-azidophenyl-substituted butanoate led to an ethyl spirodienone ...
Aza-Wittig Reaction in Natural Product Syntheses
F Palacios, C Alonso, D Aparicio… - Organic Azides: …, 2010 - books.google.com
Staudinger and Meyers reported in 1919 the first example of an aza-Wittig reagent (Scheme 15.1). 1 These phosphorus reagents are named λ5-phosphazenes,
iminophosphoranes or phosphine imines although, in this account, we will use the general term, phosphazenes. ...
A One-Pot Azido Reductive Tandem Mono-N-Alkylation Employing Dialkylboron Triflates: Online ESI-MS Mechanistic Investigation
N Shankaraiah, N Markandeya… - The Journal of …, 2011 - ACS Publications
An efficient one-pot reductive tandem mono-N-alkylation of both aromatic and aliphatic azides using dialkylboron triflates as alkylating agents has been
examined under standardized reaction conditions. This methodology after optimization has been employed ...
[C]Time-resolved resonance
raman and density functional
J Xue， 薛佳丹 - Polymer, 2006 - hub.hku.hk
Arylnitrenium ions are important intermediates in the carcinogensis of aromatic amines but
they are difficult to study because they are very reactive species and have very short
lifetimes at physiologically relevant temperatures. In this thesis, nanosecond time-resolved ...
they are difficult to study because they are very reactive species and have very short
lifetimes at physiologically relevant temperatures. In this thesis, nanosecond time-resolved ...
Copper catalyzed synthesis of 1-aryl-1, 2, 3-triazoles from aryl iodides, alkynes, and sodium azide
Y Chen, ZJ Zhuo, DM Cui, C Zhang - Journal of Organometallic Chemistry, 2014 - Elsevier
Abstract Aryl azides were synthesized using heterogeneous porous Cu (0) catalyst via a coupling reaction of aryl iodides with sodium azide under mild
conditions. Under the same conditions, one-pot Cu-catalyzed azide–alkyne cycloaddition of aryl iodides, alkynes, and ...
罗匹尼罗中间体 2-甲基-3-硝基苯乙酸的合成
李康， 杨兆琪， 文富华， 孙平华 - 中国药房, 2007 - 万方数据资源系统
摘要: 目的: 采用新方法合成罗匹尼罗中间体2-甲基-3-硝基苯乙酸. 方法: 以2-甲基-3-
硝基苯甲醛为原料, 采用环合, 氧化2 步反应进行制备, 并用质谱鉴别. 结果:
制得化合物确证为罗匹尼罗中间体2-甲基-3-硝基苯乙酸, 总收率73.6%. 结论: 本方法简便, 且 ...
硝基苯甲醛为原料, 采用环合, 氧化2 步反应进行制备, 并用质谱鉴别. 结果:
制得化合物确证为罗匹尼罗中间体2-甲基-3-硝基苯乙酸, 总收率73.6%. 结论: 本方法简便, 且 ...
17
Citaciones
Carbon-carbon bond formations involving organochromium (III) reagents
A Fürstner - Chemical reviews, 1999 - ACS Publications
CrCl3 in diethyl ether are most notable, although neither the available analytical methods nor the theoretical understanding of a chemical bond at
that time permitted determination of the structure of the resulting bis (benzene) chromium species. 1 The correct interpretation
...
The aza-Wittig reaction: an efficient tool for the construction of carbon–nitrogen double bonds
F Palacios, C Alonso, D Aparicio, G Rubiales… - Tetrahedron, 2007 - Elsevier
Recent advances in the aza-Wittig reaction of phosphazene derivatives with several carbonyl compounds are reviewed. Phosphazenes afford
inter-and intramolecular aza-Wittig
reactions with different compounds such as aldehydes, ketones, esters, thioesters, amides ...
reactions with different compounds such as aldehydes, ketones, esters, thioesters, amides ...
Synthesis of Optically Active Vasicinone Based on Intramolecular Aza-Wittig Reaction and Asymmetric Oxidation1
S Eguchi, T Suzuki, T Okawa… - The Journal of …, 1996 - ACS Publications
Both optical isomers of a quinazoline alkaloid, vasicinone, were synthesized by two different methods. The first method used (3
S)-3-hydroxy-γ-lactam as a chiral synthon, which was,
after O-TBDMS protection, o-azidobenzoylated followed by treatment with tri-n- ...
after O-TBDMS protection, o-azidobenzoylated followed by treatment with tri-n- ...
Reaction of N-Vinylic Phosphazenes Derived from β-Amino Acids with Aldehydes. Azadiene-Mediated Synthesis of Dihydropyridines, Pyridines, and Polycyclic …
F Palacios, E Herrán, G Rubiales - The Journal of Organic …, 1999 - ACS Publications
Enamino phosphonium salts 2 are obtained by 1, 2-addition of hydrogen chloride to N-
vinylic phosphazenes 1 derived from triphenylphosphine. Aza-Wittig reaction of phosphazenes 1 derived from triphenylphosphine and 6 derived from ...
vinylic phosphazenes 1 derived from triphenylphosphine. Aza-Wittig reaction of phosphazenes 1 derived from triphenylphosphine and 6 derived from ...
A Tandem Approach to Isoquinolines from 2-Azido-3-arylacrylates and α-Diazocarbonyl Compounds
YY Yang, WG Shou, ZB Chen, D Hong… - The Journal of Organic …, 2008 - ACS Publications
2-Azido-3-arylacrylates react with α-diazocarbonyl compounds and triphenylphosphine to furnish isoquinolines in 60− 92% yields. The tandem
process involves a Wolff rearrangement, an aza-Wittig reaction, and an electrocyclic ring closure. The procedure is ...
Reaction of N-vinylic phosphazenes with α, β-unsaturated aldehydes. Azatriene-mediated synthesis of dihydropyridines and pyridines derived from β-amino acids
F Palacios, E Herrán, C Alonso… - The Journal of …, 2006 - ACS Publications
Aza-Wittig reaction of N-vinylic phosphazenes (1, 2 addition), derived from diphenylmethylphosphine or derived from trimethylphosphine with α,
β-unsaturated aldehydes, leads to the formation of 3-azatrienes through a [2+ 2]-cycloaddition- ...
Addition of Organochromium Reagents to Carbonyl Compounds
K Takai - Organic Reactions, 2004 - Wiley Online Library
Organochromium compounds can be prepared by two methods:(1) transmetallation from the corresponding organolithium,—magnesium, or—zinc
compounds with chromium (III) halides, and (2) reduction of organic substrates, such as organic halides and unsaturated ...
Diastereoselective synthesis of cularine alkaloids via enium ions and an easy entry to isoquinolines by aza-Wittig electrocyclic ring closure
JAR Rodrigues, RA Abramovitch… - The Journal of …, 2004 - ACS Publications
In preliminary communications, we reported the diastereoselective synthesis of cularine and sarcocapnine via the intramolecular ring closure
of nitrenium and oxenium ions, a new highly diastereoselective reductive methylation with (+)-8-phenylmenthyl chloroacetate
...
Reaction of N-Vinylic phosphazenes with carbonyl compounds. Reactivity of the vinyl side chain versus Aza-Wittig reaction
F Palacios, D Aparicio, JM de los Santos - Tetrahedron, 1996 - Elsevier
N-Vinylic phosphazenes 2 are obtained by Staudinger reaction of conjugated azides 1 and phosphines. Reactions of phosphazenes 2a, b derived
from triphenylphosphine with
carbonyl compounds 3 involve the γ-carbon atom of the vinyl side chain as nucleophilic ...
carbonyl compounds 3 involve the γ-carbon atom of the vinyl side chain as nucleophilic ...
Synthesis of functionalized isoquinolines via sequential cyclization/cross-coupling reactions
X Yu, J Wu - Journal of Combinatorial Chemistry, 2009 - ACS Publications
CuX2-mediated cyclization of 2-alkynylbenzaldehyde O-methyl oximes in N, N-
dimethylacetamide (DMA) gave rise to 4-chloroisoquinolines in good yield, which underwent
the palladium-catalyzed cross-coupling reactions of arylboronic acids subsequently to ...
dimethylacetamide (DMA) gave rise to 4-chloroisoquinolines in good yield, which underwent
the palladium-catalyzed cross-coupling reactions of arylboronic acids subsequently to ...
Regioselective cycloaddition of 3-azatrienes with enamines. Synthesis of pyridines derived from β-aminoacids
F Palacios, E Herrán, C Alonso, G Rubiales - Tetrahedron, 2006 - Elsevier
Aza-Wittig reaction of N-vinylic phosphazenes with α, β-unsaturated aldehydes leads to the formation of 3-azatrienes through a [2+
2]-cycloaddition–cycloreversion process. Subsequent, regioselective [4+ 2]-cycloaddition of 3-azatrienes with ...
[PDF][PDRegioselective synthesis of dihydropyridines and pyridines derived from β-aminoacids from N-vinylic phosphazenes
F Palacios, E Herrán, C Alonso, G Rubiales - ARKIVOC, 2007 - pdf.easechem.com
Abstract Reaction of enamino-phosphonium salts derived from β-aminoacids with α, β-unsaturated aldehydes leads to the formation of
symmetrical dihydropyridines. Moreover, no symmetrical dihydropyridines can be obtained by the reaction of enamino-phosphonium
...
The Chemistry of Vinyl, Allenyl, and Ethynyl Azides
K Banert - Organic Azides–Syntheses and Applications, 2010 - books.google.com
The parent compound of vinyl azide 1 has been known for about hundred years when Forster and Newman prepared and characterized
this compound (Scheme 5.1). 1 However, after publication of this first example of vinyl azides, these compounds were ignored for
...
[LIBRO][B] Aplicaciones sintéticas de aniones de complejos fosfina borano y fosforil fosfacenos
CMA Sánchez - 2003 - books.google.com
El VIH-1 es un retrovirus que causa el síndrome de immunodeficiencia adquirido (SIDA) en los seres humanos. 1 Durante la
replicación del virus, el RNA mensajero transcribe genes virales y los traduce a poliproteínas, las cuales se unen a la proteasa
viral para generar ...
Synthesis of isoquinolines through the coupling of Fischer carbene complexes with< i> o</i>-alkynylpyridine carbonyl derivatives
S Mukherjee, GP Jana, BK Ghorai - Journal of
Organometallic Chemistry, 2009 - Elsevier
The reaction of Fischer carbene complex with o-alkynylpyridine carbonyl derivatives has been investigated. This involves the
generation of furo [3, 4-c] pyridine as transient intermediates through the coupling of o-alkynylpyridine carbonyl derivatives
with carbene ...
Microwave Assisted Synthesis of Monoazanaphthalene Scaffolds
W Cieslik, M Serda, A Kurczyk… - Current
Organic …, 2013 - ingentaconnect.com
Abstract: Current achievements in the microwave-assisted synthesis of quinoline and isoquinoline are discussed in this review.
Monoazanaphthalenes are important scaffolds in organic synthesis and especially in drug design. Due to their frequent appearance
in ...
Investigations into the use of Ring Closing Metathesis to form 5-, 6-, 7-and 8-membered benzo-fused heterocycles
JL Panayides - 2005 - wiredspace.wits.ac.za
The first part of the dissertation involves the use of ring closing metathesis (RCM) and ruthenium mediated isomerisation-RCM
tandem reactions to form a wide range of nitrogencontaining benzo-fused heterocycles. Those synthesized include the 6-...